23andcolm

The idea here is to keep track of projects carried out using my genotypes from 23&me. So far, I have data on ancestry, traits, carrier status and disease risk, but it will be interesting to see how I can add to what 23&me currently provides no longer provides!

Of most interest are:

- imputation to increase the number of SNPs

- polygenic scoring: where do I fall along the distribution of polygenic loading for e.g. schizophrenia?

- various ways to explore the most damaging SNPs I have, e.g. polyphen2, SIFT

- runs of homozygosity analysis

- do I have any interesting copy-number variants?

I will add to these ideas when/if I come up with more.

Please get in touch if you would like any advice on playing around with your own 23andMe data: colm _at_ broadinstitute.org

Day-17 - functional annotation with VEP and LOFTEE — Oct 28, 2014 12:40:24 PM

Day-16 - more imputation — Oct 24, 2014 8:58:52 PM

23andGG — Sep 5, 2013 8:05:09 PM

Day-15 - More CNVs — Oct 24, 2011 11:36:35 PM

Day-14 - CNVs — Jul 22, 2011 2:54:06 PM

Day-13 - PLINK annotation — Jul 20, 2011 1:56:05 PM

Day-12 - Promethease revisited — Jul 14, 2011 8:00:46 PM

Day-11 - population genetics — Jul 14, 2011 7:47:16 PM

Day-10 - NHGRI GWAS catalogue — Jul 13, 2011 2:44:00 PM

Day-09 - OMIM — Jul 11, 2011 4:10:05 PM

Day-08 - SIFT, GRAIL and STRING — Jul 11, 2011 3:11:20 PM

Day-07 - polyphen2 screening for damaging SNPs — Jul 6, 2011 4:19:31 PM

Day-06 - imputation — Jun 20, 2011 3:10:32 PM

Day-05 - resources that use 23&me data — Jun 15, 2011 8:29:41 PM

Day-04 - Alzheimer's risk — Jun 2, 2011 6:12:38 PM

Day-03 - polygenic scoring — Feb 27, 2011 4:23:17 AM

Day-02 - polygenic scoring — Jan 30, 2011 5:57:58 AM

Day-01 - data received — Jan 25, 2011 10:18:10 PM